William W. Cohen's A Computer Scientist's Guide to Cell Biology: A travelogue PDF

By William W. Cohen

ISBN-10: 038748275X

ISBN-13: 9780387482750

ISBN-10: 0387482784

ISBN-13: 9780387482781

This useful advisor presents a succinct therapy of the overall innovations of mobilephone biology, furnishing the pc scientist with the instruments essential to learn and comprehend present literature within the field.

The e-book explores 3 diverse features of biology: biological structures, experimental methods, and language and nomenclature. After a quick advent to cellphone biology, the textual content specializes in the rules at the back of the most-widely used experimental systems and mechanisms, bearing on them to well-understood strategies in desktop technology.

The presentation of the fabric has been ready for the reader’s fast snatch of the subject: reviews on nomenclature and heritage notes should be ascertained at a look, and crucial vocabulary is boldfaced in the course of the textual content for simple identification.

Computer technological know-how researchers, execs and computing device technology scholars will locate this an incomparable source and a very good start line for a extra finished exam of cellphone biology.

"This concise ebook is a superb advent for desktop scientists to the intriguing revolution below approach in molecular biology. It offers lucid, high-level descriptions of the elemental molecular mechanisms of existence, and discusses the computational ideas concerned. I want this little gem used to be on hand while i used to be ‘learning the ropes’– it'll were my first number of analyzing material."

--Roni Rosenfeld, Carnegie Mellon University

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Extra info for A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land

Sample text

As another example of “user predicates” in biology, consider a situation in which we have a mixture M of many proteins, and a particular protein X that we know binds to some of the proteins in M. How could we determine which ones? Let us assume for a moment that we have some way of easily detecting X—for instance, we’ve done something clever so that X is radioactive, or perhaps it’s been labeled to that it glows bright green. One possibility would be to construct a 2D gel M, and then use a sheet of slightly absorbent material to blot up the proteins in the gel, while preserving their relative positions.

Electron microscopes can, a protein that forms in principle, resolve objects 10,000 times microfilaments, long filaments which help give a smaller than optical microscopes—in cell its shape. practice, however, current electron microscopes improve resolution by “only” a factor of 100. This makes it possible to see very small objects indeed. Figure 25 shows electron microscope images of a number of very small objects. Electron microscopes have some disadvantages, however. Electrons, unlike light, do not penetrate very far into a cell.

Coli produces lactose-importing proteins only when lactose is present, and glucose is not. Figure 10: How E. coli responds to nutrients 22 A Computer Scientist’s Guide to Cell Biology individual interactions can be quantitatively complex. To take an example, increases in glucose might increase the quantity of cAMP linearly—but often there will be complex non-linear relationships between the parts of a biological chemical pathway. The reason for this is that most biological reactions are mediated by enzymes—proteins that encourage a chemical change, without participating in that change.

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A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land by William W. Cohen


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